Έρευνα – Δημοσιεύσεις

Ειδικά ερευνητικά ενδιαφέροντα

Ο Δρ. Λυκούδης συμμετέχει ενεργά σε μεγάλο αριθμό ερευνητικών προγραμμάτων. Τα ειδικά του ενδιαφέροντα εστιάζονται στα παρακάτω αντικείμενα:

  • Βιολογία του καρκίνου του παγκρέατος
  • Χειρουργική αντιμετώπιση προχωρημένου καρκίνου παγκρέατος
  • Βιολογία του καρκίνου του ήπατος
  • Χειρουργική αντιμετώπιση ηπατικών μεταστάσεων
  • Χειρουργική εκπαίδευση
  • Μεθοδολογία της έρευνας

Οι εξειδικευμένες του γνώσεις κι η μεγάλη του εμπειρία στην έρευνα έχουν αναγνωριστεί από σημαντικά, διεθνή, έγκριτα επιστημονικά περιοδικά, στα οποία συμμετέχει ως μέλος της Ομάδας Επιμέλειας. Από το 2014 έχει τον ρόλο του Academic Editor στο περιοδικό Medicine (Baltimore), ενώ πρόσφατα ορίστηκε ως μέλος στο Board of Associate Editors του περιοδικού British Journal of Surgery, ενός από τα ιστορικότερα και μεγαλύτερα περιοδικά Χειρουργικής στον κόσμο.

Επιπλέον, συνεισφέρει ως κριτής υποβεβλημένων άρθρων (reviewer) σε μεγάλο αριθμό διεθνών ιατρικών περιοδικών.

Ενδεικτικά αναφέρονται:

Από το 2019 συμμετέχει ως κριτής/σχολιαστής στο πρόγραμμα McMaster Online Rating of Evidence (MORE™), του ομώνυμου Πανεπιστημίου του Καναδά.

Δημοσιεύσεις

Με πάνω από 60 δημοσιεύσεις, ο Δρ. Λυκούδης συμβάλλει ενεργά στην ιατρική πρόοδο.

  1. IL-22BP controls the progression of liver metastasis in colorectal cancer.

    Giannou, A. D. Kempski, J. Zhang, T. Lucke, J. Shiri, A. M. Zazara, D. E. Belios, I. Machicote, A. Seeger, P. Agalioti, T. Tintelnot, J. Sagebiel, A. Tomczak, M. Bauditz, L. Bedke, T. Kocheise, L. Mercanoglu, B. Fard-Aghaie, M. Giorgakis, E. Lykoudis, P. M. Pikouli, A. Grass, J. K. Wahib, R. Bardenhagen, J. Brunswig, B. Heumann, A. Ghadban, T. Dupree, A. Tachezy, M. Melling, N. Arck, P. C. Stringa, P. Gentilini, M. V. Gondolesi, G. E. Nakano, R. Thomson, A. W. Perez, D. Li, J. Mann, O. Izbicki, J. R. Gagliani, N. Maroulis, I. C. Huber, S. (2023). Front Oncol 13: 1170502

  2. Clinical effects and adverse events associated with desflurane use in adult patients undergoing supratentorial craniotomy: A systematic review
    G. Gkantinas, E. Tataki, P. M. Lykoudis, E. Lelekaki, P. Kouki (2023). J Neurosurg Anesthesiol (online ahead of print)

  3. A critical role of the IL-22 – IL-2 binding protein axis in hepatocellular carcinoma
    Giannou, J. Lücke, D. Kleinschmidt, A. Mustafa Shiri, B. Steglich, M. Nawrocki, T. Zhang, D. E. Zazara, J. Kempski, L. Zhao, O. Giannou, T. Agalioti, L. Brockmann, F. Bertram, M. Sabihi, M. Böttcher, F. Ewald, K. Schulze, J. von Felden, A. Machicote, I. C. Maroulis, P. C. Arck, JK. Grass, B. Mercanoglu, M. Reeh, S. Wolter, M. Tachezy, H. Seese, M. Theodorakopoulou, P. M. Lykoudis, A. Heumann, F. G. Uzunoglu, T. Ghadban, O. Mann, J. R. Izbicki, J. Li, A. Duprée, N. Melling, N. Gagliani, S. Huber (2022). Cancers 14: 6019

  4. Plasma brain Natriuretic Peptide levels in children with chronic kidney disease and renal transplant recipients: A single center study
    Garoufi, A. Koumparelou, V. Askiti, P. Lykoudis, A. Mitsioni, S. Drapanioti, G. Servos, M. Papadaki, D. Gourgiotis, A. Marmarinos (2022). Children 9: 916
  5. When the Going Gets Tough, the Tough Get Going: Improving the Disaster Preparedness of Health Care Providers: A Single Center’s 4-Year Experience
    Pikoulis, E. Karamagioli, A. Kalogeropoulos, A. Pikoulis, P. Lykoudis, K. Remick, D. Malone, A. Kushner, B. Domres, A.i Leppäniemi, A. Exadaktylos, E. Elster, N. Rich (2022). Disaster Med Public Health Prep 16: 520-530.
  6. Colorectal Surgery in the COVID-19 Era: A Systematic Review and Meta-Analysis.
    Pararas, A. Pikouli, D. Papaconstantinou, G. Bagias, C. Nastos, A. Pikoulis, D. Dellaportas, P. Lykoudis, E. Pikoulis (2022). Cancers 14: 1229
  7. Robotic-assisted harvest of latissimus dorsi muscle flap for breast reconstruction: review of the literature
    A. Vourtsis, A. Paspala, P. M. Lykoudis, E. Spartalis, G. Tsourouflis, D. Dimitroulis, E. Pikoulis, N. Nikiteas (2022). J Robot Surg 16: 15-19
  8. Estrogen receptor expression in pancreatic adenocarcinoma: Time to reconsider evidence
    M. Lykoudis, J. Contis (2021). Pancreas 50: 1250-1253
  9. Pancreatic enzyme replacement therapy in patients with pancreatic cancer: A national prospective study
    RICOCHET Study Group (2021). Pancreatology 21: 1127-1134
  10. Current evidence on laparoscopic vs. open resection for gastric stromal tumours
    Iordanou, C. A. Theodoridis, P. M. Lykoudis, D. Dimitroulis, N. Machairas, E. Spartalis, P. Kouki, E. Pikoulis, N. Nikiteas (2021). Oncol Lett 22: 734.
  11. Bilirubin is a specific marker for the diagnosis of acute appendicitis.
    Zosimas, P. M. Lykoudis, G. Strano, J. Burke, E. Al-Cerhan, V. Shatkar (2021). Exp Ther Med 22: 1056.
  12. Portal vein resection during pancreaticoduodenectomy for pancreatic neuroendocrine tumors. An international multicenter comparative study
    K. Fusai, D. Tamburrino, S. Partelli, P. Lykoudis, P. Pipan, F. Di Salvo, N. Beghdadi, S. Dokmak, D. Wiese, L. Landoni, C Nessi, O.R.C. Busch, N. Napoli, J. Jang, W. Kwon, M. Del Chiaro, C. Scandavini, M. Abu-Awwad, T. Armstrong, M. Abu Hilal, P. J. Allen, A. Javed, M. Kjellman, A. Sauvanet, D. K. Bartsch, C. Bassi, M. Nieveen van Dijkum, M.G. Besselink, U. Boggi, S. Kim, J. He, C. L. Wolfgang, M Falconi (2020). Surgery 169: 1093-1101.
  13. An invited commentary on" No alteration of CYP3A4 activity after major hepatectomy in early postoperative period-A prospective before-after study"
    A. Theodoridis, P. M. Lykoudis (2020). Int J Surg 84: 50.
  14. Optimal extent of initial parathyroid resection in patients with multiple endocrine neoplasia syndrome type 1: A meta-analysis
    Nastos, D. Papaconstantinou, E. Kofopoulos-Lymperis, M. Peppa, A. Pikoulis, P. Lykoudis, F. Palazzo, P. Patapis, E. Pikoulis (2020). Surgery 169: 302-310.
  15. An invited commentary on" One-stitch versus traditional method of protective loop ileostomy in laparoscopic low anterior rectal resection: A retrospective comparative study”
    V Kollaras, P.M. Lykoudis (2020). Int J Surg 83:
  16. An invited commentary on" incisional hernia after liver transplantation: Risk factors, management strategies and long-term outcomes of a cohort study".
    M. Lykoudis, B. R. Davidson (2020). Int J Surg 80: 40.
  17. Laparostomy and temporary abdominal closure outcomes in emergency non-trauma surgery and parameters affecting early definite primary fascial closure.
    Zosimas, P.M. Lykoudis (2020). Minerva Chir 75: 419-425.
  18. Commentary on “the results of pancreatic operations after the implementation of multidisciplinary team conference (MDT): A quality improvement study”.
    M. Lykoudis, V. Ntomi (2020). Int J Surg 78: 118-119.
  19. An invited commentary on "critical appraisal of the techniques of pancreatic anastomosis following pancreaticoduodenectomy: A network meta-analysis".
    M. Lykoudis (2020). Int J Surg 77: 117.
  20. Development of a structured virtual reality curriculum for laparoscopic appendicectomy.
    Sinitsky, B. Fernando, H. Potts, P. Lykoudis, G. Hamilton and P. Berlingieri (2020). Am J Surg 219(4): 613-621.
  21. Tumour length as an independent prognostic factor in resectable oesophageal carcinoma.
    Vadhwana, D. Zosimas, P.M. Lykoudis, H.M. Phen, M. Martinou and D. Khoo (2020). Ann R Coll Surg Engl 102(3): 185-190.
  22. Recipient body mass index and infectious complications following liver transplantation.
    Diaz-Nieto, P.M. Lykoudis, B.R. Davidson (2019). HPB 21: 1032-1038.
  23. A simple scoring model for predicting early graft failure and postoperative mortality after liver transplantation.
    Diaz-Nieto, P. Lykoudis, F. Robertson, D. Sharma, K. Moore, M. Malago, B.R. Davidson (2019). Ann Hepatol 18(6): 902-912.
  24. Treatment challenges in and outside a specialist network setting: pancreatic neuroendocrine tumours.
    M. Lykoudis, S. Partelli, F. Muffatti, M. Caplin, M. Falconi and G. Fusai (2019). Eur J Surg Oncol 45(1): 46-51.
  25. A novel technique to avoid sentinel lymph node dissection in patients with a preoperative diagnosis of ductal cancer in situ and its implementations on current practice.
    Karakatsanis, A. Hersi, L. Pistiolis, R. Olofsson Bagge, P.M. Lykoudis, S. Eriksson and F. Wärnberg (2019). Br J Surg 106(6): 720-728.
  26. Improving patient flow in a busy acute NHS hospital: the surgical hot clinic
    Strano, D. Zosimas, P.M. Lykoudis, A Mansuri and V. Shatkar (2019). Br J Hosp Med 80(4): 234-235.
  27. Postoperative outcomes in laparoscopic appendicectomies with histopathologically normal appendix.
    Zosimas, P.M. Lykoudis, J. Burke, G. Strano, P. Leung and V. Shatkar (2019). Ann Ital Chir 90: 72-77.
  28. Critical care usage after major gastrointestinal and liver surgery: a prospective, multicentre observational study.
    STARSurg Collaborative (2019). Br J Anaesth 122(1): 42-50.
  29. Adjuvant radiotherapy in oesophageal cancer with positive circumferential resection margins - recurrence and survival outcomes.
    Vadhwana, D. Zosimas, P.M. Lykoudis, H. M. Phen, M. Martinou, T. Amalesh, D. Khoo (2019). J Gastrointest Oncol 10(3): 483-491.
  30. Vascular stapler for transection of pancreatic parenchyma in laparoscopic distal pancreatectomy
    Sahay, P.M. Lykoudis, A. Al Midani, A. Haswell and S. Rahman (2019). Am Surg 85(6): e275-e276.
  31. Single port laparoscopic total and subtotal colectomies for inflammatory bowel disease in a district general hospital.
    Zosimas, A. Mansouri, P.M. Lykoudis, M. Wain, J. Huang (2019). J Laparoendosc Adv Surg Tech 29(11):1431-1435.
  32. Outcomes after distal pancreatectomy with celiac axis resection for pancreatic cancer: A pan-European retrospective cohort study.
    E-AHPBA DP-CAR study group (2018). Ann Surg Oncol 25(5): 1440-1447.
  33. Role of colectomy in preventing recurrent primary sclerosing cholangitis in liver transplant recipients.
    M. Buchholz, P.M. Lykoudis, R. Ravikumar, J.M. Pollok, G.K. Fusai (2018). World J Gastroenterol 24(28): 3171-3180.
  34. Development and implementation of a virtual reality laparoscopic colorectal training curriculum.
    Wynn, P.M. Lykoudis and P. Berlingieri (2018). Am J Surg 216(3):610-617.
  35. Impact of postoperative intravenous fluid administration on complications following elective hepato-pancreato-biliary surgery.
    Martin, P.M. Lykoudis, G. Jones, D. Highton, A. Shaw, S. James, Q. Wei and G. Fusai (2018). Hepatobiliary Pancreat Dis Int 17(5): 402-407.
  36. Body mass index and complications following major gastrointestinal surgery: A prospective, international cohort study and meta-analysis.
    EuroSurg Collaborative (2018). Colorectal Dis. 20(8): O215-O225.
  37. Open versus laparoscopic appendicectomy in acute appendicitis: results of a district general hospital.
    Zosimas, P.M. Lykoudis, A. Pilavas, P. Leung, G Strano and V Shatkar (2018). S Afr J Surg 56(2): 59-62.
  38. Survivin expression as an independent predictor of overall survival in pancreatic adenocarcinoma. J. Contis, M. Lykoudis, K. Goula, D. Karandrea and A. Kondi-Pafiti (2018). Journal of Cancer Research and Therapeutics 14 (S3): 719-723.
  39. Safety of Nonsteroidal Anti-inflammatory Drugs in Major Gastrointestinal Surgery: A Prospective, Multicenter Cohort Study.
    STARSurg Collaborative (2017). World J Surg 41(1): 47-55.
  40. Laparoscopic cholecystectomy in patients with ventriculoperitoneal shunts: A case series.
    M. Lykoudis, C. Nastos, D. Dellaportas, A. Vezakis, G.D. Ayiomamitis, I. Papaconstantinou, T. Theodosopoulos, A. Polydorou and G. Polymeneas (2017). Hellenic J Surg 89(34): 163165.
  41. Prognostic Evaluation of Vimentin Expression in Correlation with Ki67 and CD44 in Surgically Resected Pancreatic Ductal Adenocarcinoma.
    Myoteri, D. Dellaportas, P.M. Lykoudis, A. Apostolopoulos, A. Marinis and A. Zizi-Sermpetzoglou (2017). Gastroenterol Res Pract 2017: 9207616.
  42. Students' participation in collaborative research should be recognised.
    STARSurg Collaborative (2017). Int J Surg 39: 234-237.
  43. Major postoperative complications after pancreatic resection for P-NETS are not associated to earlier recurrence.
    Valente, P. Lykoudis, D. Tamburrino, M. Inama, I. Passas, C. Toumpanakis, T. V. Luong, B. Davidson, C. Imber, M. Malago, S. H. Rahman, A. Shankar, D. Sharma, M. Caplin and G. Fusai (2017). Eur J Surg Oncol 43(11): 2119-2128.
  44. Malignant peripheral nerve sheath tumour of the oesophagus Review of the literature and report of a case with lymph node and distant metastases.
    K. Mavroeidis, K. Kandilaris, D.I. Matthioudakis, S.N. Kaza, P.M. Lykoudis, F. Saffioti and M. Demonakou (2017). Ann Ital Chir 88: 26-38.
  45. Extended lymph node dissection in pancreaticoduodenectomy? A case-control study.
    Dellaportas, N. Arkadopoulos, P.M. Lykoudis, D. Myoteri, A. Psyrri, P. Vassiliou, P. Athanasopoulos, A. Polydorou, I. Vasiliou and V. Smyrniotis (2017). Journal of the Pancreas 18(1): 49-53.
  46. Is ultrasound a reliable diagnostic tool for acute appendicitis? A single centre experience.
    Zosimas, P.M. Lykoudis, P. Leung, G. Strano and V. Shatkar (2017) Ann Ital Chir 88: 557-561.
  47. Multicentre prospective cohort study of body mass index and postoperative complications following gastrointestinal surgery.
    STARSurg Collaborative (2016). Br J Surg 103(9): 1157-1172.
  48. Giant Pancreatic Retention Cyst Secondary to Chronic Pancreatitis: Report of a Case.
    Zosimas, P.M. Lykoudis, R. Kumar and A. Shankar (2016). Hong Kong Journal of Paediatrics 21(1): 43-45.
  49. Preoperative ultrasound guided percutaneous axillary biopsy in breast cancer patients: fine needle aspiration cytology versus core biopsy.
    Zosimas, P.M. Lykoudis and R. Vashisht (2016). Ann Ital Chir 87: 509-16.
  50. Contrast-Enhanced Color Doppler Ultrasonography for Preoperative Evaluation of Sentinel Lymph Node in Breast Cancer Patients.
    Dellaportas, A. Koureas, J. Contis, P.M. Lykoudis, I. Vraka, D. Psychogios, A. Kondi-Pafiti and D. K. Voros (2015). Breast Care (Basel) 10(5): 331-335.
  51. Laparoscopic left lateral hepatectomy for colorectal metastasis is the standard of care.
    J. Sahay, F. Fazio, F. Cetta, H. Chouial, P.M. Lykoudis and G. Fusai (2015). J BUON 20(4): 1048-1053.
  52. Major Hepatectomy for Colorectal Metastases in the Elderly: A Tertiary Center Experience.
    Damrah, P.M. Lykoudis, R. Orti-Rodriguez, T. Pissanou, D. Sharma, K. Rolles, B. Davidson and G. Fusai (2015). International Surgery 100(9-10): 1276-1280.
  53. Uncommon benign lesions of the adrenal glands mimicking sinister pathologies: report of 8 cases. M. Lykoudis, C. Nastos, D. Dellaportas, E. Kairi-Vassilatou, C. Dastamani and A. Kondi-Pafiti (2015). J BUON 20(6): 1630-1634.
  54. Systematic review of surgical management of synchronous colorectal liver metastases.
    M. Lykoudis, D. O'Reilly, K. Nastos and G. Fusai (2014). Br J Surg 101(6): 605-612.
  55. Effect of infliximab on the healing of intestinal anastomosis. An experimental study in rats.
    Papaconstantinou, C. Zeglinas, M. Gazouli, K. Nastos, A. Yiallourou, P. Lykoudis, K. Evangelou, A. Papalois, M. Papaioannou, J. Vlachogiannakos and C. Tzathas (2014). Int J Surg 12(9): 969-975.
  56. Bilateral obturator pyomyositis with visceral involvement in an immunocompetent adult patient treated without surgery.
    Karakatsanis, P. Lykoudis, C. Nastos, E. Chronopoulos, V. Koutoulidis, G. Polymeneas and D. Voros (2014). Surg Infect (Larchmt) 15(5): 651-655.
  57. Global consequences of liver ischemia/reperfusion injury.
    Nastos, K. Kalimeris, N. Papoutsidakis, M. K. Tasoulis, P.M. Lykoudis, K. Theodoraki, D. Nastou, V. Smyrniotis and N. Arkadopoulos (2014). Oxid Med Cell Longev 2014: 906965.
  58. Tumour budding is a strong and independent prognostic factor in pancreatic cancer.
    Karamitopoulou, I. Zlobec, D. Born, A. Kondi-Pafiti, P. Lykoudis, A. Mellou, K. Gennatas, B. Gloor and A. Lugli (2013). Eur J Cancer 49(5): 1032-1039.
  59. Correlation of the ICG test with risk factors and postoperative outcomes following hepatic resection.
    K. Derpapas, J. Contis, G.P. Fragulidis, P.M. Lykoudis, G. Polymeneas, S. Ntourakis and D. Voros (2013). J BUON 18(3): 703-707.
  60. Expression of microRNAs in patients with pancreatic cancer and its prognostic significance.
    G. Papaconstantinou, A. Manta, M. Gazouli, A. Lyberopoulou, P.M. Lykoudis, G. Polymeneas and D. Voros (2013). Pancreas 42(1): 67-71.
  61. Peritoneal mesotheliomas mimicking adnexal tumors. Clinicopathological characteristics of four cases and a short literature review.
    Dellaportas, E. Kairi-Vassilatou, P. Lykoudis, P. Mavrigiannaki, S. Mellou, C.K. Kleanthis and A. Kondi-Pafiti (2012). Eur J Gynaecol Oncol 33(1): 101-104.
  62. A review on the role of microRNA in biology, diagnosis, and treatment of pancreatic adenocarcinoma.
    G. Papaconstantinou, P.M. Lykoudis, M. Gazouli, A. Manta, G. Polymeneas and D. Voros (2012). Pancreas 41(5): 671-677.
  63. Stenting of a gastroduodenal artery aneurysm: report of a case.
    M. Lykoudis, V.K. Stafyla, V. Koutoulidis, A. Xatziioannou, N. Arkadopoulos, I. Mourikis and V. Smyrniotis (2012). Surg Today 42(1): 72-74.
  64. Arteriovenous malformation: An unusual cause of rectus sheath hematoma, following laparoscopic cholecystectomy.
    Dellaportas, P.G. Athanasopoulos, P. Lykoudis, A. Manta, V. Koutoulidis, A.N. Chatziioannou, G. Polymeneas and T. Theodosopoulos (2011). Int J Surg Case Rep 2(5): 79-81.
  65. Solitary adrenal metastasis from esophageal adenocarcinoma: a case report and review of the literature.
    Dellaportas, P. Lykoudis, G. Gkiokas, G. Polymeneas, A. Kondi-Pafiti and D. Voros (2011). Case Rep Med 2011: 487875.
  66. A large fibrolamellar hepatocellular carcinoma in a 17-year-old male body builder.
    Dellaportas, P. Lykoudis, A. Tsagkas, D. Voros and A. Kondi-Pafiti (2011). J BUON 16(4): 780.
  67. Subcutaneous granular cell tumour of the lumbar region.
    Fragulidis, K. Chondrogiannis, P. Lykoudis, A. Karakatsanis, C. Georgiou, E. Vouza and A. Melemeni (2011). J Cutan Aesthet Surg 4(2): 132-134.
  68. Cystoid gossypiboma of the liver 15 years after cholecystectomy.
    P. Fragulidis, K.D. Chondrogiannis, A. Karakatsanis, P.M. Lykoudis, A. Melemeni, A. Polydorou and D. Voros (2011). Am Surg 77(1): E17-18.
  69. Appendiceal neuroma without obliteration of the lumen mimicking acute appendicitis.
    Papaconstantinou, A. Karakatsanis, P. Lykoudis, E. Karvouni and G. Polymeneas (2011). Chirurgia 24(3): 143-145.
  70. A case of hepatic flexure carcinoid with extended brain metastases.
    I. Papaconstantinou, P.M. Lykoudis, J.C. Contis, G.S. Limouris and D.T. Trafalis (2011). J BUON 16(4): 779-780.

Στα πλαίσια διεθνών ερευνητικών πρωτοκόλλων, ο Δρ. Λυκούδης συνεργάζεται με σημαντικά Κέντρα του Εξωτερικού, όπως το Νοσοκομείο Royal Free του Λονδίνου, την Ιατρική Σχολή του University College London και το Πανεπιστημιακό Νοσοκομείο του Αμβούργου.